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Solvent Evaporation Techniques as Promising Advancement in Microencapsulation

Nagiat T Hwisa, Prakash Katakam, Babau Rao Chandu, Shanta Kumari Adiki


In recent times solvent evaporation techniques have gained prominence in microencapsulation process. Solvent evaporation techniques are broadly classified into emulsification solvent- evaporation and extraction methods. Several variations have been developed recently based on this technology. Using solvent evaporation methods we can regulate microsphere morphology and other characteristics to the desired level for the targeted delivery of bioactives like peptides and vaccines using various biomaterials as carriers. Several methods of solvent evaporation, core and coat materials used, emulsion stabilizers, and process variables were discussed in detail with due interest of recent advancements in this area of research. This technology is showing a promising future for drug targeting and throwing challenges to pharmaceutical scientist such as: scale-up problems, use of non-organic solvents, use of alternative biodegradable polymers, and the application of a viable hybrid technology by amalgamating various techniques of microencapsulation to overcome the problems of peptide degradation during the process and stability of microspheres after the process.


Solvent Evaporation, Solvent Extraction, New Modifications, Review.

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