Open Journal Systems

Cover Image

Creation and designing of PENN Database for natural molecules effective against age related disorders

Neelam Jain, Sanjana M Bhat, Teesta V Katte, Avnish Bhattrai, Sahana Rao, Pradeep S, Savithri Bhat

Abstract


PENN Database  (Plant Extracted Natural molecules for Neurodegeneration) is online database (www.penndatabase.info) dedicated to various neurodegenerative disorders such as Parkinson’s, Alzheimer’s, Huntington’s, Amyotrophic lateral sclerosis and Creutzfeldt Jacob’s and several  natural molecules known to prevent and/or cure these age related diseases. To each of the natural molecules link for pubchem and pubmed is provided through respective CIDs and PMIDs. Mysql was used for designing and creation of the database while the language of programming applied for creating the database is php. Further, web page designing and online accessibility of database is accomplished by html and css. The PENN database provides links for details of individual molecules making it a useful and versatile online tool. The information in the database could be exploited for designing of experiments to  study comparative effects of natural molecules on  neurodegenerative diseases.

Keywords


Protein misfolding disorder, Database, Natural molecule, Mysql, php scripting language

Full Text:

PDF PDFPlus

References


Trojanowski JQ, Arnold SE, Karlawish JH, Brunden K, Cary M, Davatzikos C, Detre J, Gaulton G, Grossman M, Hurtig H, et al.: Design of comprehensive Alzheimer's disease centers to address unmet national needs. Alzheimer's & dementia : the journal of the Alzheimer's Association 2010, 6:150-155.

Rutkowski DT, Hegde RS: Regulation of basal cellular physiology by the homeostatic unfolded protein response. The Journal of cell biology 2010, 189:783-794.

http://dx.doi.org/10.1083/jcb.201003138

PMid:20513765 PMCid:PMC2878945

Hegde RS, Ploegh HL: Quality and quantity control at the endoplasmic reticulum. Current opinion in cell biology 2010, 22:437-446.

http://dx.doi.org/10.1016/j.ceb.2010.05.005

PMid:20570125 PMCid:PMC2929805

Morimoto RI: Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging. Genes & development 2008, 22:1427-1438.

http://dx.doi.org/10.1101/gad.1657108

PMid:18519635 PMCid:PMC2732416

Chiti F, Dobson CM: Protein misfolding, functional amyloid, and human disease. Annu. Rev. Biochem. 2006, 75:333-366.

http://dx.doi.org/10.1146/annurev.biochem.75.101304.123901

PMid:16756495

Sutherland BA, Rahman R, Appleton I: Mechanisms of action of green tea catechins, with a focus on ischemia-induced neurodegeneration. The Journal of nutritional biochemistry 2006, 17:291-306.

http://dx.doi.org/10.1016/j.jnutbio.2005.10.005

PMid:16443357

RajaSankar S, Manivasagam T, Sankar V, Prakash S, Muthusamy R, Krishnamurti A, Surendran S: Withania somnifera root extract improves catecholamines and physiological abnormalities seen in a Parkinson's disease model mouse. Journal of Ethnopharmacology 2009, 125:369-373.

http://dx.doi.org/10.1016/j.jep.2009.08.003

PMid:19666100

Pyrzanowska J, Piechal A, Blecharz-Klin K, Lehner M, Skórzewska A, Turzyńska D, Sobolewska A, Plaznik A, Widy-Tyszkiewicz E: The influence of the long-term administration of< i> Curcuma longa extract on learning and spatial memory as well as the concentration of brain neurotransmitters and level of plasma corticosterone in aged rats. Pharmacology Biochemistry and Behavior 2010, 95:351-358.

http://dx.doi.org/10.1016/j.pbb.2010.02.013

PMid:20219527




DOI: http://dx.doi.org/10.14259%2Fbp.v2i1.66

Refbacks

  • There are currently no refbacks.